Before Using This medicine: Do not take this medicine if you are allergic to any ingredient in this medicine, you have heart, brain, or peripheral blood vessel disease, you have a history of heart disease, or heart attack; you have other types of migraine headaches (hemiplegic, basilar, or cluster headaches); you have chest pain; you have had a stroke or transient ischemic attack; you have ischemic bowel disease; you have uncontrolled high blood pressure; you are currently taking or have taken a monoamine oxidase (MAO) inhibitor within the last 14 days; you have used other migraine medications (eg, ergot-containing medications or another 5-HT1 agonist) within the last 24 hours; you have severe liver disease.

Other Medical Problems: Imitrex is a headache medicine. It is believed to work by causing vasoconstriction (narrowing) of blood vessels (arteries and veins) around the brain. Imitrex also reduces the release of substances in the body that contribute to headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. Imitrex is used to treat vascular headaches such as migraine and cluster headaches. Imitrex will not prevent migraines or cluster headaches or reduce the number of attacks. It will only treat a migraine or cluster headache that is already occurring.

Proper Use of This Medicine: Take 1 tablet at onset of headache. May repeat in 24 hrs if necessary.

Precautions While Using This Medicine: Do not use Imitrex if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) within the last 14 days. The combination could cause seizures, nausea, vomiting, sweating, flushing, and dizziness.

Side Effects of This Medicine: Every medicine can cause side effects, but many people have no, or minor, side effects. Tell your doctor or pharmacist if any of the following occurs: Severe allergic reactions (rash; hives; difficulty breathing; swelling of the mouth, face, lips, or tongue); serious heart problems; chest pain, pressure, heaviness, or tightness. Common: Abnormal skin sensations; warm/cold sensations. Other: Nausea; vomiting; migraine; headache; decreased salivation; dizziness; drowsiness/sleepiness; chest, jaw, or neck tightness, pressure, or pain; pain; feeling of a whirling motion; tiredness.